In a large bowl, gently combine ground beef with Worcestershire sauce, liquid smoke, salt, pepper, garlic powder, and onion powder.
Divide into 4 portions and shape into thin, wide patties (about 5 inches across).
Heat a grill, grill pan, or skillet over medium-high heat.
Cook patties 3–4 minutes per side, until browned and cooked through (160°F internal temperature).
Add cheese in the last minute if making Whoppers with cheese.
Lightly toast the sesame seed buns on the grill or skillet until golden brown.
Spread 1 tablespoon mayonnaise on the bottom bun. Add lettuce, tomato, and the beef patty.
Layer with pickles, onion slices, and ketchup.
Add the top bun and serve hot.